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閲覧数:228
ID 76291075
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本文 TohoJMed002004123.pdf
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タイトル High Postoperative Neutrophil-Lymphocyte Ratio is Associated with Poor Outcomes After Curative Resection for Locally Advanced Gastric Cancer
別タイトル
著者
Akihiro, Suzuki
Department of Gastrointestinal Surgery, St. Luke’s International Hospital, Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Hideaki, Shimada
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Keisuke, Kubota
Department of Gastrointestinal Surgery, St. Luke’s International Hospital
[役割]Author
Osamu, Takahashi
Department of Biostatistics, St. Luke’s International University
[役割]Author
Akihiro, Kishida
Department of Gastrointestinal Surgery, St. Luke’s International Hospital
[役割]Author
Hironori, Kaneko
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
出版地 Tokyo
出版者 The Medical Society of Toho University
形態
上位タイトル
Toho Journal of Medicine (Toho Journal of Medicine). Vol.2, No.4  (2016. 12) ,p.123- 128
識別番号
ISSN
21891990
DOI
URI
JaLCDOI info:doi/10.14994/tohojmed.2016.027
抄録 Background: Neutrophil-lymphocyte ratio (NLR) is associated with the inflammatory status of patients with some cancers. We tested the hypothesis that postoperative NLR (post-NLR) was associated with outcomes in patients with stage II/III gastric cancer. Methods: We retrospectively analyzed data from 193 patients with stage II/III gastric cancer who underwent curative gastrectomy at St. Luke's International Hospital between 2000 and 2012. All patients underwent baseline staging, including blood testing, computed tomography, and endoscopic biopsy. The association of post-NLR with clinical outcomes was analyzed by univariate and multivariate analyses. Results: Average age was 67.7 (95% confidence interval, 43.5 ― 91.9) years, and most patients were male. After surgery, 92 (47.7%) patients underwent adjuvant chemotherapy. Median follow-up time was 78.4 (95% confidence interval, 70.3 ― 86.6) months. In univariate analyses, age, stage, preoperative NLR, baseline carbohydrate antigen (CA)19-9 level, postoperative white blood cell count, postoperative hemoglobin level, post-NLR, and adjuvant chemotherapy were associated with overall survival (OS). In multivariate analyses, age (p<0.01), stage (p<0.01), and post-NLR (p<0.01) were associated with OS. When the post-NLR cutoff value was set at 3, outcomes were worse for patients with high post-NLR than for those with low post-NLR (p<0.001). Conclusions: High post-NLR was associated with poor OS and recurrence-free survival in patients with locally advanced gastric cancer, which indicates that post-NLR might be a useful marker for individualized therapy.
キーワード
neutrophil-lymphocyte ratio
postoperative inflammation
gastric cancer
prognostic indicator
adjuvant chemotherapy
NDC
注記 Original Article
言語
eng
資源タイプ TOHO University Scholarly Publication
ジャンル Journal Article
著者版フラグ publisher
アクセス条件 東邦大学医学会
Index
/ Public / Toho Journal of Medicine / Vol.2 / No.4(p.106-128)
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