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閲覧数:197
ID 51178109
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本文 TohoJMed002004119.pdf
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タイトル Supplementation with Oral Magnesium Oxide, 750 - 1980 mg Daily, Did Not Reduce Cisplatin-Induced Nephrotoxicity
別タイトル
著者
Kosuke, Nishizawa
Department of Pharmacy, Toho University Omori Medical Center
[役割]Author
Yoshiki, Arita
Department of Pharmacy, Toho University Omori Medical Center
[役割]Author
Hideaki, Shimada
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Takashi, Suzuki
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Tatsuki, Nanami
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Yoko, Oshima
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Satoshi, Yajima
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Kenji, Nishizawa
Department of Pharmacy, Toho University Omori Medical Center
[役割]Author
出版地 Tokyo
出版者 The Medical Society of Toho University
形態
上位タイトル
Toho Journal of Medicine (Toho Journal of Medicine). Vol.2, No.4  (2016. 12) ,p.119- 122
識別番号
ISSN
21891990
DOI
URI
JaLCDOI info:doi/10.14994/tohojmed.2016.004
抄録 Introduction: Hypomagnesemia is a side effect of chemotherapy with cisplatin-containing regimens and can increase cisplatin-induced nephrotoxicity. Previous reports found that oral magnesium supplementation significantly reduced the decline in serum magnesium levels after cisplatin treatment. However, few studies have assessed the effect of magnesium oxide on serum magnesium levels after cisplatin treatment. We retrospectively evaluated the effect of supplementation with oral magnesium oxide, 750 ― 1980 mg daily, for treatment of constipation on cisplatin-induced nephrotoxicity in patients receiving high-dose cisplatin therapy. Methods: We retrospectively reviewed data from 161 patients treated with cisplatin-containing regimens between January 2011 and December 2014. Using the Common Terminology Criteria for Adverse Events, version 4.0, we compared the incidence of grade 2 or higher serum creatinine elevation in patients who did (n = 21) and did not (n = 140) receive magnesium oxide for treatment of constipation during a first course of cisplatin chemotherapy. Results: Mean change in serum creatinine level was similar (0.29±0.50 mg/dl in the control group vs 0.34±0.58 mg/dl in the magnesium oxide supplementation group; p = 0.69). Nephrotoxicity was observed in 15 patients, but there was no significant difference in incidence between groups. Change in creatinine clearance after cisplatin treatment did not differ between groups. Conclusions: Supplementation with oral magnesium oxide, 750 - 1980 mg daily, did not reduce cisplatin-induced nephrotoxicity.
キーワード
cisplatin
magnesium
nephrotoxicity
NDC
注記 Original Article
言語
eng
資源タイプ TOHO University Scholarly Publication
ジャンル Journal Article
著者版フラグ publisher
アクセス条件 東邦大学医学会
Index
/ Public / Toho Journal of Medicine / Vol.2 / No.4(p.106-128)
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