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閲覧数:54
ID 22227757
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本文 TohoJMed003002058.pdf
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URI
タイトル Perioperative Monitoring of Serum p53 Antibody Titers in Japanese Women Undergoing Surgical Treatment After Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer
別タイトル
著者
Kubota, Yorichika
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Shimada, Hideaki
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Saito, Fumi
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Nemoto, Tetsuo
Department of Surgical Pathology (Omori), School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Ogata, Hideaki
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
Kaneko, Hironori
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
[役割]Author
出版地 Tokyo
出版者 The Medical Society of Toho University
形態
上位タイトル
Toho Journal of Medicine (Toho Journal of Medicine). Vol.3, No.2  (2017. 6) ,p.58- 65
識別番号
ISSN
21891990
DOI
URI
JaLCDOI info:doi/10.14994/tohojmed.2017.002
抄録 Background: The clinicopathological relevance of serum p53 antibodies (s-p53-Abs) in advanced breast cancer is not well understood. We evaluated the clinicopathological importance of s-p53-Abs titers in patients after surgical treatment and neoadjuvant chemotherapy for breast cancer. Methods: We retrospectively analyzed the records of 43 consecutive female patients with primary locally advanced breast cancer who were surgically treated after neoadjuvant chemotherapy at Toho University Omori Medical Center between January 2010 and December 2014. S-p53-Abs, carcinoembryonic antigen (CEA), and cancer antigen (CA) 15-3 were assessed perioperatively, and the clinicopathological relevance of these tumor markers was analyzed. Results: Eleven (26%) patients were s-p53-Abs ― positive; however, s-p53-Abs status was not associated with any clinicopathological feature. Three of these 11 patients developed recurrence. The rate of positive test results for CEA and/or s-p53-Abs was significantly higher than that for CEA alone (44% vs 21%, respectively; p = 0.04). In addition, the positive rate for CA15-3 and/or s-p53-Abs was higher than that for CA15-3 alone (53% vs 33%, respectively; p = 0.08). The s-p53-Abs titer decreased in 10 of 11 (91%) patients after surgery and increased in 1 patient, who later developed brain metastasis. Seven patients with positive s-p53-Abs titers seroconverted and did not develop recurrence. In contrast, s-p53-Abs titers remained positive in 3 patients, 2 of whom developed brain metastases. Conclusions: Perioperative monitoring of s-p53-Abs titers may be useful in detecting residual cancer cells. Extremely high s-p53-Abs titers suggest an increased risk of brain metastasis.
キーワード
serum p53 antibodies
locally advanced breast cancer
neoadjuvant chemotherapy
brain metastasis
perioperative monitoring
NDC
注記 Original Article
言語
eng
資源タイプ TOHO University Scholarly Publication
ジャンル Journal Article
著者版フラグ publisher
アクセス条件 東邦大学医学会
Index
/ Public / Toho Journal of Medicine / Vol.3 / No.2(p.50-74)
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